Although the severity of Down syndrome ranges from mild to severe, most individuals with Down syndrome have widely recognizable physical characteristics. These include:
- a flattened face and nose, a short neck, a small mouth sometimes with a large, protruding tongue, small ears, upward slanting eyes that may have small skin folds at the inner corner (epicanthal fold);
- white spots (also known as Brushfield spots) may be present on the colored part of the eye (iris);
- the hands are short and broad with short fingers, and with a single crease in the palm;
- poor muscle tone and loose ligaments are also common; and
- development and growth is usually delayed and often average height and developmental milestones are not reached.